Wednesday, April 2, 2008

Synthetic Estrogens Wreak Havoc On Your Reproductive System

Researchers are developing a clearer understanding of why the synthetic estrogens found in many widely-used plastics can cause damage to a developing fetus, fertility problems, and vaginal and breast cancers.

Past research has shown that exposure to the synthetic estrogen diethylstilbestrol (DES) alters the expression of HOXA10, a gene necessary for uterine development. By studying the DNA of the offspring of 30 pregnant mice injected with DES, researchers found changes in certain regions of the HOXA10 gene that continued beyond the time of development and persisted into adulthood.

HOXA 10 protein expression was shifted to the bottom portion of the uterus in the female offspring, indicating that DES is actually changing the structure of the HOXA 10 gene.

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